El proyecto de aplicaciones bioinformaticas para el análisis de microorganismos está enfocado a realizar análisis computacional de mutaciones del virus de la hepatitis C (VHC) asociados a resistencia a los antivirales de acción directa (AAD). La infección crónica por el VHC sigue siendo un grave problema de salud pública a nivel mundial, afectando a 200 millones de personas y ocasionando unas 10.000 muertes al año. Por tanto es importante determinar la variabilidad del VHC en los genes NS3, NS5A y NS5B, diana de AAD, para poder determinar su posible impacto en el tratamiento con nuevos AAD en pacientes infectados con VHC, prevenir potenciales fallos terapéuticos y optimizar los futuros regímenes terapéuticos, escogiendo los AAD más adecuados para cada paciente.

• Año de Inicio: 2013-01-01
• Autores
• Hector Florez
• Karina Salvatierra
• Software
• PSSA
• BMA
• Publicaciones
• Artículos en Revista
1. Salvatierra Karina, Vera Marcos, Lloret María Antonia, Florez Hector. In Silico Docking Study: Antiviral Activity of Sofosbuvir Against NS5 Protein from Sika Virus. . ISSN: . vol:. p:. (2018).
2. Salvatierra Karina, Florez Hector, Lopez Labrador Xavier. Coevolution Analysis of Proteins NS3 and NS5B of Hepatitis C Virus in Geotype 1B Isolates. . ISSN: . vol:. p:. (2018).
3. Salvatierra Karina, Florez Hector. Bioinformatics Approach to Analyze Influenza Viruses. Communications in Computer and Information Science. ISSN:1865-0929. vol:916. p:442-452. (2018).
4. Guardiola Mauro, Salvatierra Karina, Florez Hector. Computer analysis of resistance mutations to HCV NS5A antivirals. International Journal of Infectious Diseases. ISSN:1201-9712. vol:73S. p:382-383. (2018).
5. Salvatierra Karina, Florez Hector. Computational analysis of resistance mutations in the hepatitis C virus. Vínculos. ISSN:1794-211X. vol:15. p:27-33. (2018).
6. Florez Hector, Salvatierra Karina. A Web-Based Approach for Analyzing Microorganism Sequences. Communications in Computer and Information Science. ISSN:1865-0929. vol:742. p:96-107. (2017).
7. Florez Hector, Salvatierra Karina. Using bioinformatics methods to analyze influenza viruses. . ISSN: . vol:. p:65-72. (2017).
8. Florez Hector, Salvatierra Karina. Bioinformatics Study of Mutations of Resistance to Antivirals in the NS5A Gen of HCV. Information. ISSN:1343-4500. vol:20 (9A). p:6665-6672. (2017).
9. Florez Hector, Salvatierra Karina. Computational analysis of resistance mutations to new direct acting antivirals in the Hepatitis C virus. . ISSN: . vol:. p:65-66. (2017).
10. Florez Hector, Salvatierra Karina. Computational analysis of E1 gene of chikungunya virus to identify genotypes. . ISSN: . vol:. p:60-61. (2017).
11. Florez Hector, Salvatierra Karina. A Tool for Analyzing Mutations in Biomedical Microorganisms. . ISSN: . vol:. p:25-33. (2017).
12. Salvatierra Karina, Florez Hector. Pathogen Sequence Signature Analysis (PSSA): A software tool for analyzing sequences to identify microorganism genotypes. F1000 Research. ISSN:2046-1402. vol:6 (21). p:1-8. (2017).
13. Salvatierra Karina, Florez Hector. Prevalence of hepatitis B and C infections in hemodialysis patients. F1000 Research. ISSN:2046-1402. vol:5 (1910). p:1-6. (2016).
14. Salvatierra Karina, Florez Hector. Biomedical Mutation Analysis (BMA): A software tool for analyzing mutations associated with antiviral resistance. F1000 Research. ISSN:2046-1402. vol:5 (1141). p:1-9. (2016).
15. Salvatierra Karina, Florez Hector. Hepatitis C virus NS3 protease resistance testing: analysis computational to detect resistance mutations. . ISSN: . vol:. p:6. (2016).
16. Salvatierra Karina, Florez Hector. Computational analysis to detect resistance mutations to direct acting antivirals in Hepatitis C virus. . ISSN: . vol:. p: 47. (2016).
17. Salvatierra Karina, Florez Hector. Análisis del Virus de la Hepatitis C en pacientes en hemodiálisis. Infectio. ISSN:0123-9392. vol:20 (3). p:130-137. (2015).
18. Florez Hector, Salvatierra Karina. Análisis computacional de mutaciones de resistencias del virus de la hepatitis C. . ISSN: . vol:. p:21. (2015).
19. Salvatierra Karina, Florez Hector. Análisis Computacional de Mutaciones de Resistencias a Inhibidores de la Proteasa NS3 Y Polimerasa NS5B del Virus de la Hepatitis C. Biomédica. ISSN:0120-4157. vol:35. p:125. (2015).
• Conferencias Académicas
1. Salvatierra Karina, Vera Marcos, Lloret María Antonia, Florez Hector. In Silico Docking Study: Antiviral Activity of Sofosbuvir Against NS5 Protein from Sika Virus. p:. Buenos Aires, Argentina. (2018).
2. Salvatierra Karina, Florez Hector, Lopez Labrador Xavier. Coevolution Analysis of Proteins NS3 and NS5B of Hepatitis C Virus in Geotype 1B Isolates. p:. Santiago, Chile. (2018).
3. Salvatierra Karina, Florez Hector. Bioinformatics Approach to Analyze Influenza Viruses. p:442-452. Medellin, Colombia. (2018).
4. Guardiola Mauro, Salvatierra Karina, Florez Hector. Computer analysis of resistance mutations to HCV NS5A antivirals. p:382-383. Buenos Aires, Argentina. (2018).
5. Salvatierra Karina, Florez Hector. Computational analysis of resistance mutations in the hepatitis C virus. p:27-33. . (2018).
6. Florez Hector, Salvatierra Karina. A Web-Based Approach for Analyzing Microorganism Sequences. p:96-107. Cartagena, Colombia. (2017).
7. Florez Hector, Salvatierra Karina. Using bioinformatics methods to analyze influenza viruses. p:65-72. Toronto, Canada. (2017).
8. Florez Hector, Salvatierra Karina. Bioinformatics Study of Mutations of Resistance to Antivirals in the NS5A Gen of HCV. p:6665-6672. Bandung, Indonesia. (2017).
9. Florez Hector, Salvatierra Karina. Computational analysis of resistance mutations to new direct acting antivirals in the Hepatitis C virus. p:65-66. Madison, Estados Unidos. (2017).
10. Florez Hector, Salvatierra Karina. Computational analysis of E1 gene of chikungunya virus to identify genotypes. p:60-61. Madison, Estados Unidos. (2017).
11. Florez Hector, Salvatierra Karina. A Tool for Analyzing Mutations in Biomedical Microorganisms. p:25-33. Orlando, Estados Unidos. (2017).
12. Salvatierra Karina, Florez Hector. Pathogen Sequence Signature Analysis (PSSA): A software tool for analyzing sequences to identify microorganism genotypes. p:1-8. . (2017).
13. Salvatierra Karina, Florez Hector. Prevalence of hepatitis B and C infections in hemodialysis patients. p:1-6. . (2016).
14. Salvatierra Karina, Florez Hector. Biomedical Mutation Analysis (BMA): A software tool for analyzing mutations associated with antiviral resistance. p:1-9. . (2016).
15. Salvatierra Karina, Florez Hector. Hepatitis C virus NS3 protease resistance testing: analysis computational to detect resistance mutations. p:6. Hyderabad, India. (2016).
16. Salvatierra Karina, Florez Hector. Computational analysis to detect resistance mutations to direct acting antivirals in Hepatitis C virus. p: 47. San José, Costa Rica. (2016).
17. Salvatierra Karina, Florez Hector. Análisis del Virus de la Hepatitis C en pacientes en hemodiálisis. p:130-137. . (2015).
18. Florez Hector, Salvatierra Karina. Análisis computacional de mutaciones de resistencias del virus de la hepatitis C. p:21. Buenos Aires, Argentina. (2015).
19. Salvatierra Karina, Florez Hector. Análisis Computacional de Mutaciones de Resistencias a Inhibidores de la Proteasa NS3 Y Polimerasa NS5B del Virus de la Hepatitis C. p:125. Bogotá, Colombia. (2015).

Por medio de la creación de metamodelos y transformaciones modelo a modelo y modelo a texto, se desea crear proyectos de software de forma semiautomática, a partir de la creación de un único modelo conceptual.

• Año de Inicio: 2013-01-01
• Autores
• Hector Florez
• Daniel Sanchez
• Oscar Mendez
• Software
• CFP
• RIS
• DevPHP
• RIWA
• PHPGen
• Publicaciones
• Libros
1. Florez Hector. Sistemas Digitales. Ediciones de la U. ISSN:978-958-762-190-7. 2014.
• Capítulos de Libro
1. Florez, Hector. Human Factors in Automated Analysis for Enterprise Models. IGI Global. ISSN:180619075135. 2019.
2. Florez Hector, Sanchez Mario, Villalobos Jorge. Drafting Enterprise Models. IGI Global. ISSN:9781522555223. 2018.
• Artículos en Revista
1. Florez Hector, Leon Marcelo. Model Driven Engineering Approach to Configure Software Reusable Components. Communications in Computer and Information Science. ISSN:1865-0929. vol:942. p:352-363. (2018).
2. Sanchez Daniel, Florez Hector. Model Driven Engineering Approach to Manage Peripherals in Mobile Devices. Lecture Notes in Computer Science. ISSN:0302-9743. vol:10963. p:353-364. (2018).
3. Sanchez Daniel, Mendez Oscar, Florez Hector. An Approach of a Framework to Create Web Applications. Lecture Notes in Computer Science. ISSN:0302-9743. vol:10963. p:341-352. (2018).
4. Sanchez Daniel, Mendez Oscar, Florez Hector. Applying the 3-layer Model in the Construction of a Framework to Create Web Applications. . ISSN: . vol:. p:364-369. (2017).
5. Florez Hector, Sanchez Mario, Villalobos Jorge. Analysis of Imprecise Enterprise Models. Lecture Notes in Business Information Processing. ISSN:1865-1348. vol:248. p:349-364. (2016).
6. Florez Hector, Sanchez Mario, Villalobos Jorge. A Catalog of Automated Analysis Methods for Enterprise Models. SpringerPlus. ISSN:2193-1801. vol:5 (406). p:1-24. (2016).
7. Florez Hector. Metamodels composition strategy for the model driven engineering context. Vínculos. ISSN:1794-211X. vol:44. p:109-120. (2015).
8. Gomez Paola, Sanchez Mario, Florez Hector, Villalobos Jorge. An Approach to the Co-creation of Models and Metamodels in Enterprise Architecture Projects. Journal of Object Technology. ISSN:1660-1769. vol:13 (3). p:1-29. (2014).
9. Florez Hector, Sanchez Mario, Villalobos Jorge. Extensible Model-based Approach for Supporting Automatic Enterprise Analysis. . ISSN: . vol:. p:32-41. (2014).
10. Florez Hector, Sanchez Mario, Villalobos Jorge. iArchiMate: A Tool for Managing Imperfection in Enterprise Models. . ISSN: . vol:. p:201-210. (2014).
11. Florez Hector, Sanchez Mario, Villalobos Jorge. Supporting Drafts for Enterprise Modeling. . ISSN: . vol:. p:200-206. (2014).
12. Florez Hector, Sanchez Mario, Villalobos Jorge. Embracing Imperfection in Enterprise Architecture Models. CEUR Workshops Proceedings. ISSN:1613-0073. vol:1023. p:8-17. (2013).
13. Florez Hector. Adapting models in metamodels composition processes. Vínculos. ISSN:1794-211X. vol:10 (1). p:96-108. (2013).
14. Florez Hector. Software Product Lines based on Model Transformation Chains. . ISSN: . vol:. p:. (2013).
• Conferencias Académicas
1. Florez Hector, Leon Marcelo. Model Driven Engineering Approach to Configure Software Reusable Components. p:352-363. Bogotá, Colombia. (2018).
2. Sanchez Daniel, Florez Hector. Model Driven Engineering Approach to Manage Peripherals in Mobile Devices. p:353-364. Melbourne, Australia. (2018).
3. Sanchez Daniel, Mendez Oscar, Florez Hector. An Approach of a Framework to Create Web Applications. p:341-352. Melbourne, Australia. (2018).
4. Sanchez Daniel, Mendez Oscar, Florez Hector. Applying the 3-layer Model in the Construction of a Framework to Create Web Applications. p:364-369. Orlando, Estados Unidos. (2017).
5. Florez Hector, Sanchez Mario, Villalobos Jorge. Analysis of Imprecise Enterprise Models. p:349-364. Ljubljana, Eslovenia. (2016).
6. Florez Hector, Sanchez Mario, Villalobos Jorge. A Catalog of Automated Analysis Methods for Enterprise Models. p:1-24. . (2016).
7. Florez Hector. Metamodels composition strategy for the model driven engineering context. p:109-120. . (2015).
8. Gomez Paola, Sanchez Mario, Florez Hector, Villalobos Jorge. An Approach to the Co-creation of Models and Metamodels in Enterprise Architecture Projects. p:1-29. . (2014).
9. Florez Hector, Sanchez Mario, Villalobos Jorge. Extensible Model-based Approach for Supporting Automatic Enterprise Analysis. p:32-41. Ulm, Alemania. (2014).
10. Florez Hector, Sanchez Mario, Villalobos Jorge. iArchiMate: A Tool for Managing Imperfection in Enterprise Models. p:201-210. Ulm, Alemania. (2014).
11. Florez Hector, Sanchez Mario, Villalobos Jorge. Supporting Drafts for Enterprise Modeling. p:200-206. Pereira, Colombia. (2014).
12. Florez Hector, Sanchez Mario, Villalobos Jorge. Embracing Imperfection in Enterprise Architecture Models. p:8-17. Riga, Letonia. (2013).
13. Florez Hector. Adapting models in metamodels composition processes. p:96-108. Cartagena, Colombia. (2013).
14. Florez Hector. Software Product Lines based on Model Transformation Chains. p:. Orlando, Estados Unidos. (2013).

Mediante la creación de aplicaciones móviles empresariales se crean soluciones de negocio específicas. Además, dichas aplicaciones contribuyen a la generación de nuevas empresas

• Año de Inicio: 2014-01-01
• Autores
• Hector Florez
• Daniel Sanchez
• Software
• Black Jack
• ARtesanias App
• TelApp
• BlackJack App
• Publicaciones
• Artículos en Revista
1. Wanumen Luis, Florez Hector. Architectural Approaches for Phonemes Recognition Systems. Communications in Computer and Information Science. ISSN:1865-0929. vol:942. p:267-279. (2018).
2. Sanchez Daniel, Florez Hector. Model Driven Engineering Approach to Manage Peripherals in Mobile Devices. Lecture Notes in Computer Science. ISSN:0302-9743. vol:10963. p:353-364. (2018).
3. Joya Juan, Prieto Karen, Florez Hector. Comunicación Síncrona Mediante Arquitectura Orientada a Servicios para Aplicaciones en Dispositivos . . ISSN: . vol:. p:422-427. (2015).
4. Rincon Sebastian, Cardenas Ivan, Florez Hector. M-Commerce basado en Realidad Aumentada. . ISSN: . vol:. p:284-289. (2015).
5. Gonzalez Angela, Barrera Ricardo, Florez Hector. M-Marketplaces para la Comercialización de Productos y Servicios. . ISSN: . vol:. p:290-294. (2015).
6. Joya Juan, Florez Hector. Communication of Mobile Devices through Bluetooth Technology. Vínculos. ISSN:1794-211X. vol:11 (2). p:92-98. (2014).
• Conferencias Académicas
1. Wanumen Luis, Florez Hector. Architectural Approaches for Phonemes Recognition Systems. p:267-279. Bogotá, Colombia. (2018).
2. Sanchez Daniel, Florez Hector. Model Driven Engineering Approach to Manage Peripherals in Mobile Devices. p:353-364. Melbourne, Australia. (2018).
3. Joya Juan, Prieto Karen, Florez Hector. Comunicación Síncrona Mediante Arquitectura Orientada a Servicios para Aplicaciones en Dispositivos . p:422-427. Cartagena, Colombia. (2015).
4. Rincon Sebastian, Cardenas Ivan, Florez Hector. M-Commerce basado en Realidad Aumentada. p:284-289. Cartagena, Colombia. (2015).
5. Gonzalez Angela, Barrera Ricardo, Florez Hector. M-Marketplaces para la Comercialización de Productos y Servicios. p:290-294. Cartagena, Colombia. (2015).
6. Joya Juan, Florez Hector. Communication of Mobile Devices through Bluetooth Technology. p:92-98. . (2014).