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<div class='card border-success'><div class='card-header bg-success text-white'><strong>Aplicaciones bioinformaticas para el análisis de microorganismos</strong></div><div class='card-body'><p>El proyecto de aplicaciones bioinformaticas para el análisis de microorganismos está enfocado a realizar análisis computacional de mutaciones del virus de la hepatitis C (VHC) asociados a resistencia a los antivirales de acción directa (AAD). La infección crónica por el VHC sigue siendo un grave problema de salud pública a nivel mundial, afectando a 200 millones de personas y ocasionando unas 10.000 muertes al año. Por tanto es importante determinar la variabilidad del VHC en los genes NS3, NS5A y NS5B, diana de AAD, para poder determinar su posible impacto en el tratamiento con nuevos AAD en pacientes infectados con VHC, prevenir potenciales fallos terapéuticos y optimizar los futuros regímenes terapéuticos, escogiendo los AAD más adecuados para cada paciente.</p><ul><li><strong>Año de Inicio: </strong>2013-01-01</li><li><strong>Autores</strong></li><ul><li>Hector Florez</li><li>Karina Salvatierra</li></ul><li><strong>Software</strong></li><ul><li>PSSA</li><li>BMA</li></ul><li><strong>Publicaciones</strong></li><ul></ul><ul></ul><ul><br />
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<li><strong>Artículos en Revista</strong></li><ol><li>Sweta Singh, Hector Florez. <u>Coronavirus disease 2019 drug discovery through molecular docking</u>. <i>F1000 Research</i>. ISSN:2046-1402. vol:9(502). p:1-9. (2020). <a href='https://doi.org/10.12688/f1000research.24218.1' target='_blank'><span class='fas fa-external-link-alt'></span></a> <a href='https://www.scimagojr.com/journalsearch.php?q=21100258853&tip=sid&clean=0' target='_blank'><img src='https://ris.itiud.org/img/sjr.png' width='25px'></a></li><li>Hector Florez, Sweta Singh. <u>Online dashboard and data analysis approach for assessing COVID-19 case and death data</u>. <i>F1000 Research</i>. ISSN:2046-1402. vol:9(570). p:1-9. (2020). <a href='https://doi.org/10.12688/f1000research.24164.1' target='_blank'><span class='fas fa-external-link-alt'></span></a> <a href='https://www.scimagojr.com/journalsearch.php?q=21100258853&tip=sid&clean=0' target='_blank'><img src='https://ris.itiud.org/img/sjr.png' width='25px'></a></li><li>Karina Salvatierra, Marcos Vera, Hector Florez. <u>Bioinformatics Methods to Discover Antivirals Against Zika Virus</u>. <i>Communications in Computer and Information Science</i>. ISSN:1865-0929. vol:1051. p:3-14. (2019). <a href='https://doi.org/10.1007/978-3-030-32475-9_1' target='_blank'><span class='fas fa-external-link-alt'></span></a> <a href='https://www.scimagojr.com/journalsearch.php?q=17700155007&tip=sid' target='_blank'><img src='https://ris.itiud.org/img/sjr.png' width='25px'></a></li><li>. <u></u>. <i></i>. ISSN:. vol:. p:. ().  </li><li>. <u></u>. <i></i>. ISSN:. vol:. p:. ().  </li><li>Karina Salvatierra, Hector Florez . <u>Bioinformatics Approach to Analyze Influenza Viruses</u>. <i>Communications in Computer and Information Science</i>. ISSN:1865-0929. vol:916. p:442-452. (2018). <a href='https://doi.org/10.1007/978-3-030-00353-1_39' target='_blank'><span class='fas fa-external-link-alt'></span></a> <a href='https://www.scimagojr.com/journalsearch.php?q=17700155007&tip=sid' target='_blank'><img src='https://ris.itiud.org/img/sjr.png' width='25px'></a></li><li>Mauro Guardiola, Karina Salvatierra, Hector Florez. <u>Computer analysis of resistance mutations to HCV NS5A antivirals</u>. <i>International Journal of Infectious Diseases</i>. ISSN:1201-9712. vol:73S. p:382-383. (2018). <a href='https://doi.org/10.1016/j.ijid.2018.04.4280' target='_blank'><span class='fas fa-external-link-alt'></span></a> <a href='https://www.scimagojr.com/journalsearch.php?q=22380&tip=sid&clean=0' target='_blank'><img src='https://ris.itiud.org/img/sjr.png' width='25px'></a></li><li>Karina Salvatierra, Hector Florez. <u>Computational analysis of resistance mutations in the hepatitis C virus</u>. <i>Vínculos</i>. ISSN:1794-211X. vol:15. p:27-33. (2018). <a href='https://doi.org/10.14483/2322939X.12973' target='_blank'><span class='fas fa-external-link-alt'></span></a> </li><li>Florez Hector, Salvatierra Karina. <u> A Web-Based Approach for Analyzing Microorganism Sequences</u>. <i>Communications in Computer and Information Science</i>. ISSN:1865-0929. vol:742. p:96-107. (2017). <a href='https://doi.org/10.1007/978-3-319-66963-2_10' target='_blank'><span class='fas fa-external-link-alt'></span></a> <a href='https://www.scimagojr.com/journalsearch.php?q=17700155007&tip=sid' target='_blank'><img src='https://ris.itiud.org/img/sjr.png' width='25px'></a></li><li>. <u></u>. <i></i>. ISSN:. vol:. p:. ().  </li><li>Florez Hector, Salvatierra Karina. <u>Bioinformatics Study of Mutations of Resistance to Antivirals in the NS5A Gen of HCV</u>. <i>Information</i>. ISSN:1343-4500. vol:20 (9A). p:6665-6672. (2017). <a href='http://www.information-iii.org/abs_e2.html#No9(A)-2017' target='_blank'><span class='fas fa-external-link-alt'></span></a> <a href='https://www.scimagojr.com/journalsearch.php?q=21100201065&tip=sid&clean=0' target='_blank'><img src='https://ris.itiud.org/img/sjr.png' width='25px'></a></li><li>. <u></u>. <i></i>. ISSN:. vol:. p:. ().  </li><li>. <u></u>. <i></i>. ISSN:. vol:. p:. ().  </li><li>Karina Salvatierra, Hector Florez. <u>Pathogen Sequence Signature Analysis (PSSA): A software tool for analyzing sequences to identify microorganism genotypes</u>. <i>F1000 Research</i>. ISSN:2046-1402. vol:6 (21). p:1-8. (2017). <a href='https://doi.org/10.12688/f1000research.10393.1' target='_blank'><span class='fas fa-external-link-alt'></span></a> <a href='https://www.scimagojr.com/journalsearch.php?q=21100258853&tip=sid&clean=0' target='_blank'><img src='https://ris.itiud.org/img/sjr.png' width='25px'></a></li><li>Karina Salvatierra, Hector Florez. <u>Prevalence of hepatitis B and C infections in hemodialysis patients</u>. <i>F1000 Research</i>. ISSN:2046-1402. vol:5 (1910). p:1-6. (2016). <a href='https://doi.org/10.12688/f1000research.9068.1' target='_blank'><span class='fas fa-external-link-alt'></span></a> <a href='https://www.scimagojr.com/journalsearch.php?q=21100258853&tip=sid&clean=0' target='_blank'><img src='https://ris.itiud.org/img/sjr.png' width='25px'></a></li><li>Karina Salvatierra, Hector Florez. <u>Biomedical Mutation Analysis (BMA): A software tool for analyzing mutations associated with antiviral resistance</u>. <i>F1000 Research</i>. ISSN:2046-1402. vol:5 (1141). p:1-9. (2016). <a href='https://doi.org/10.12688/f1000research.8740.2' target='_blank'><span class='fas fa-external-link-alt'></span></a> <a href='https://www.scimagojr.com/journalsearch.php?q=21100258853&tip=sid&clean=0' target='_blank'><img src='https://ris.itiud.org/img/sjr.png' width='25px'></a></li><li>. <u></u>. <i></i>. ISSN:. vol:. p:. ().  </li><li>. <u></u>. <i></i>. ISSN:. vol:. p:. ().  </li><li>Karina Salvatierra, Hector Florez. <u>Análisis del Virus de la Hepatitis C en pacientes en hemodiálisis</u>. <i>Infectio</i>. ISSN:0123-9392. vol:20 (3). p:130-137. (2015). <a href='https://doi.org/10.1016/j.infect.2015.10.002' target='_blank'><span class='fas fa-external-link-alt'></span></a> <a href='https://www.scimagojr.com/journalsearch.php?q=21100317205&tip=sid&clean=0' target='_blank'><img src='https://ris.itiud.org/img/sjr.png' width='25px'></a></li><li>. <u></u>. <i></i>. ISSN:. vol:. p:. ().  </li><li>Karina Salvatierra, Hector Florez. <u>Análisis Computacional de Mutaciones de Resistencias a Inhibidores de la Proteasa NS3 Y Polimerasa NS5B del Virus de la Hepatitis C</u>. <i>Biomédica</i>. ISSN:0120-4157. vol:35. p:125. (2015). <a href='http://www.revistabiomedica.org/index.php/biomedica/article/view/3084/2869' target='_blank'><span class='fas fa-external-link-alt'></span></a> <a href='https://www.scimagojr.com/journalsearch.php?q=77291&tip=sid' target='_blank'><img src='https://ris.itiud.org/img/sjr.png' width='25px'></a></li></ol><li><strong>Conferencias Académicas</strong></li><ol><li>Karina Salvatierra, Marcos Vera, Hector Florez. <u>Bioinformatics Methods to Discover Antivirals Against Zika Virus</u>. p:3-14. Madrid, España. (2019). <a href='https://doi.org/10.1007/978-3-030-32475-9_1' target='_blank'><span class='fas fa-external-link-alt'></span></a></li><li>. <u></u>. . (). </li><li>. <u></u>. . (). </li><li>Karina Salvatierra, Hector Florez . <u>Bioinformatics Approach to Analyze Influenza Viruses</u>. p:442-452. Medellin, Colombia. (2018). <a href='https://doi.org/10.1007/978-3-030-00353-1_39' target='_blank'><span class='fas fa-external-link-alt'></span></a></li><li>Florez Hector, Salvatierra Karina. <u> A Web-Based Approach for Analyzing Microorganism Sequences</u>. p:96-107. Cartagena, Colombia. (2017). <a href='https://doi.org/10.1007/978-3-319-66963-2_10' target='_blank'><span class='fas fa-external-link-alt'></span></a></li><li>. <u></u>. . (). </li><li>. <u></u>. . (). </li><li>. <u></u>. . (). </li><li>Hector Florez, Karina Salvatierra. <u>A Tool for Analyzing Mutations in Biomedical Microorganisms</u>. p:25-33. Orlando, Estados Unidos. (2017). <a href='https://www.iiis.org/CDs2017/CD2017Spring/papers/ZA934YA.pdf' target='_blank'><span class='fas fa-external-link-alt'></span></a></li><li>. <u></u>. . (). </li><li>. <u></u>. . (). </li><li>. <u></u>. . (). </li></ol></ul><ul></div></div><br><div class='card border-success'><div class='card-header bg-success text-white'><strong>Diseño de soluciones en el contexto de ingenía dirigida por modelos</strong></div><div class='card-body'><p>Por medio de la creación de metamodelos y transformaciones modelo a modelo y modelo a texto, se desea crear proyectos de software de forma semiautomática, a partir de la creación de un único modelo conceptual.</p><ul><li><strong>Año de Inicio: </strong>2013-01-01</li><li><strong>Autores</strong></li><ul><li>Hector Florez</li><li>Daniel  Sanchez</li><li>Oscar Mendez</li></ul><li><strong>Software</strong></li><ul><li>CFP</li><li>RIS</li><li>DevPHP</li><li>RIWA</li><li>PHPGen</li></ul><li><strong>Publicaciones</strong></li><ul><li><strong>Libros</strong></li><ol><li>Hector Florez. <u>Sistemas Digitales</u>. Ediciones de la U. ISSN:978-958-762-190-7. 2014. <a href='https://www.libreriadelau.com/sistemas-digitales--principios--analisis-y-dise%C3%B1o/p' target='_blank'><span class='fas fa-external-link-alt'></span></a></li></ol></ul><ul><li><strong>Capítulos de Libro</strong></li><ol><li>Hector Florez. <u>Human Factors in Automated Analysis for Enterprise Models</u>. IGI Global. ISSN:180619075135. 2019. <a href='https://www.igi-global.com/gateway/chapter/239467' target='_blank'><span class='fas fa-external-link-alt'></span></a></li><li>Hector Florez, Mario Sanchez, Jorge Villalobos. <u>Drafting Enterprise Models</u>. IGI Global. ISSN:9781522555223. 2019. <a href='https://www.igi-global.com/chapter/drafting-enterprise-models/219167' target='_blank'><span class='fas fa-external-link-alt'></span></a></li></ol></ul><ul><br />
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<li><strong>Artículos en Revista</strong></li><ol><li>Hector Florez, Edwarth Garcia, Deisy Muñoz . <u>Automatic Code Generation System for Transactional Web Applications</u>. <i>Lecture Notes in Computer Science</i>. ISSN:0302-9743. vol:11623. p:436-451. (2019). <a href='https://doi.org/10.1007/978-3-030-24308-1_36' target='_blank'><span class='fas fa-external-link-alt'></span></a> <a href='https://www.scimagojr.com/journalsearch.php?q=25674&tip=sid' target='_blank'><img src='https://ris.itiud.org/img/sjr.png' width='25px'></a></li><li>Hector Florez, Marcelo Leon. <u>Model Driven Engineering Approach to Configure Software Reusable Components</u>. <i>Communications in Computer and Information Science</i>. ISSN:1865-0929. vol:942. p:352-363. (2018). <a href='https://doi.org/10.1007/978-3-030-01535-0_26' target='_blank'><span class='fas fa-external-link-alt'></span></a> <a href='https://www.scimagojr.com/journalsearch.php?q=17700155007&tip=sid' target='_blank'><img src='https://ris.itiud.org/img/sjr.png' width='25px'></a></li><li>Daniel Sanchez, Hector Florez. <u>Model Driven Engineering Approach to Manage Peripherals in Mobile Devices</u>. <i>Lecture Notes in Computer Science</i>. ISSN:0302-9743. vol:10963. p:353-364. (2018). <a href='https://doi.org/10.1007/978-3-319-95171-3_28' target='_blank'><span class='fas fa-external-link-alt'></span></a> <a href='https://www.scimagojr.com/journalsearch.php?q=25674&tip=sid' target='_blank'><img src='https://ris.itiud.org/img/sjr.png' width='25px'></a></li><li>Daniel Sanchez, Oscar Mendez, Hector Florez . <u>An Approach of a Framework to Create Web Applications</u>. <i>Lecture Notes in Computer Science</i>. ISSN:0302-9743. vol:10963. p:341-352. (2018). <a href='https://doi.org/10.1007/978-3-319-95171-3_27' target='_blank'><span class='fas fa-external-link-alt'></span></a> <a href='https://www.scimagojr.com/journalsearch.php?q=25674&tip=sid' target='_blank'><img src='https://ris.itiud.org/img/sjr.png' width='25px'></a></li><li>Hector Florez, Mario Sanchez, Jorge Villalobos. <u>Analysis of Imprecise Enterprise Models</u>. <i>Lecture Notes in Business Information Processing</i>. ISSN:1865-1348. vol:248. p:349-364. (2016). <a href='https://doi.org/10.1007/978-3-319-39429-9_22' target='_blank'><span class='fas fa-external-link-alt'></span></a> <a href='https://www.scimagojr.com/journalsearch.php?q=17500155101&tip=sid&clean=0' target='_blank'><img src='https://ris.itiud.org/img/sjr.png' width='25px'></a></li><li>Hector Florez, Mario Sanchez, Jorge Villalobos. <u>A Catalog of Automated Analysis Methods for Enterprise Models</u>. <i>SpringerPlus</i>. ISSN:2193-1801. vol:5 (406). p:1-24. (2016). <a href='https://doi.org/10.1186/s40064-016-2032-9' target='_blank'><span class='fas fa-external-link-alt'></span></a> <a href='https://www.scimagojr.com/journalsearch.php?q=21100228569&tip=sid&clean=0' target='_blank'><img src='https://ris.itiud.org/img/sjr.png' width='25px'></a></li><li>Hector Florez. <u>Metamodels composition strategy for the model driven engineering context</u>. <i>Tecnura</i>. ISSN:0123-921X. vol:44. p:109-120. (2015). <a href='https://doi.org/10.14483/udistrital.jour.tecnura.2015.2.a09' target='_blank'><span class='fas fa-external-link-alt'></span></a> </li><li>Paola Gómez, Mario Sánchez, Hector Florez, Jorge Villalobos. <u>An Approach to the Co-creation of Models and Metamodels in Enterprise Architecture Projects</u>. <i>Journal of Object Technology</i>. ISSN:1660-1769. vol:13 (3). p:1-29. (2014). <a href='https://doi.org/10.5381/jot.2014.13.3.a2' target='_blank'><span class='fas fa-external-link-alt'></span></a> <a href='https://www.scimagojr.com/journalsearch.php?q=28360&tip=sid&clean=0' target='_blank'><img src='https://ris.itiud.org/img/sjr.png' width='25px'></a></li><li>Hector Florez, Mario Sanchez, Jorge Villalobos. <u>Embracing Imperfection in Enterprise Architecture Models</u>. <i>CEUR Workshops Proceedings</i>. ISSN:1613-0073. vol:1023. p:8-17. (2013). <a href='http://ceur-ws.org/Vol-1023/' target='_blank'><span class='fas fa-external-link-alt'></span></a> <a href='https://www.scimagojr.com/journalsearch.php?q=21100218356&tip=sid&clean=0' target='_blank'><img src='https://ris.itiud.org/img/sjr.png' width='25px'></a></li><li>Hector Florez. <u> Adapting models in metamodels composition processes</u>. <i>Vínculos</i>. ISSN:1794-211X. vol:10 (1). p:96-108. (2013). <a href='https://doi.org/10.14483/2322939X.4664' target='_blank'><span class='fas fa-external-link-alt'></span></a> </li><li>. <u></u>. <i></i>. ISSN:. vol:. p:. ().  </li></ol><li><strong>Conferencias Académicas</strong></li><ol><li>Hector Florez, Edwarth Garcia, Deisy Muñoz . <u>Automatic Code Generation System for Transactional Web Applications</u>. p:436-451. San Petesburgo, Rusia. (2019). <a href='https://doi.org/10.1007/978-3-030-24308-1_36' target='_blank'><span class='fas fa-external-link-alt'></span></a></li><li>Hector Florez, Marcelo Leon. <u>Model Driven Engineering Approach to Configure Software Reusable Components</u>. p:352-363. Bogotá, Colombia. (2018). <a href='https://doi.org/10.1007/978-3-030-01535-0_26' target='_blank'><span class='fas fa-external-link-alt'></span></a></li><li>Daniel Sanchez, Hector Florez. <u>Model Driven Engineering Approach to Manage Peripherals in Mobile Devices</u>. p:353-364. Melbourne, Australia. (2018). <a href='https://doi.org/10.1007/978-3-319-95171-3_28' target='_blank'><span class='fas fa-external-link-alt'></span></a></li><li>Daniel Sanchez, Oscar Mendez, Hector Florez . <u>An Approach of a Framework to Create Web Applications</u>. p:341-352. Melbourne, Australia. (2018). <a href='https://doi.org/10.1007/978-3-319-95171-3_27' target='_blank'><span class='fas fa-external-link-alt'></span></a></li><li>Daniel Sanchez, Oscar Mendez, Hector Florez . <u>Applying the 3-layer Model in the Construction of a Framework to Create Web Applications</u>. p:364-369. Orlando, Estados Unidos. (2017). <a href='https://www.iiis.org/CDs2017/CD2017Spring/papers/ZA356NC.pdf' target='_blank'><span class='fas fa-external-link-alt'></span></a></li><li>Hector Florez, Mario Sanchez, Jorge Villalobos. <u>Analysis of Imprecise Enterprise Models</u>. p:349-364. Ljubljana, Eslovenia. (2016). <a href='https://doi.org/10.1007/978-3-319-39429-9_22' target='_blank'><span class='fas fa-external-link-alt'></span></a></li><li>Hector Florez, Mario Sanchez, Jorge Villalobos. <u>Extensible Model-based Approach for Supporting Automatic Enterprise Analysis</u>. p:32-41. Ulm, Alemania. (2014). <a href='https://doi.org/10.1109/EDOC.2014.15' target='_blank'><span class='fas fa-external-link-alt'></span></a></li><li>Hector Florez, Mario Sanchez, Jorge Villalobos. <u> iArchiMate: A Tool for Managing Imperfection in Enterprise Models</u>. p:201-210. Ulm, Alemania. (2014). <a href='https://doi.org/10.1109/EDOCW.2014.38' target='_blank'><span class='fas fa-external-link-alt'></span></a></li><li>Hector Florez, Mario Sanchez, Jorge Villalobos. <u>Supporting Drafts for Enterprise Modeling</u>. p:200-206. Pereira, Colombia. (2014). <a href='https://doi.org/10.1109/ColumbianCC.2014.6955334' target='_blank'><span class='fas fa-external-link-alt'></span></a></li><li>Hector Florez, Mario Sanchez, Jorge Villalobos. <u>Embracing Imperfection in Enterprise Architecture Models</u>. p:8-17. Riga, Letonia. (2013). <a href='http://ceur-ws.org/Vol-1023/' target='_blank'><span class='fas fa-external-link-alt'></span></a></li><li>. <u></u>. . (). </li></ol></ul><ul></div></div><br><div class='card border-success'><div class='card-header bg-success text-white'><strong>Aplicaciones móviles en contextos empresarial</strong></div><div class='card-body'><p>Mediante la creación de aplicaciones móviles empresariales se crean soluciones de negocio específicas. Además, dichas aplicaciones contribuyen a la generación de nuevas empresas</p><ul><li><strong>Año de Inicio: </strong>2014-01-01</li><li><strong>Autores</strong></li><ul><li>Hector Florez</li><li>Daniel  Sanchez</li></ul><li><strong>Software</strong></li><ul><li>Black Jack</li><li>ARtesanias App</li><li>TelApp</li><li>BlackJack App</li></ul><li><strong>Publicaciones</strong></li><ul></ul><ul></ul><ul><br />
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<li><strong>Artículos en Revista</strong></li><ol><li>Luis Wanumen, Hector Florez. <u>Architectural Approaches for Phonemes Recognition Systems</u>. <i>Communications in Computer and Information Science</i>. ISSN:1865-0929. vol:942. p:267-279. (2018). <a href='https://doi.org/10.1007/978-3-030-01535-0_20' target='_blank'><span class='fas fa-external-link-alt'></span></a> <a href='https://www.scimagojr.com/journalsearch.php?q=17700155007&tip=sid' target='_blank'><img src='https://ris.itiud.org/img/sjr.png' width='25px'></a></li><li>Daniel Sanchez, Hector Florez. <u>Model Driven Engineering Approach to Manage Peripherals in Mobile Devices</u>. <i>Lecture Notes in Computer Science</i>. ISSN:0302-9743. vol:10963. p:353-364. (2018). <a href='https://doi.org/10.1007/978-3-319-95171-3_28' target='_blank'><span class='fas fa-external-link-alt'></span></a> <a href='https://www.scimagojr.com/journalsearch.php?q=25674&tip=sid' target='_blank'><img src='https://ris.itiud.org/img/sjr.png' width='25px'></a></li><li>. <u></u>. <i></i>. ISSN:. vol:. p:. ().  </li><li>. <u></u>. <i></i>. ISSN:. vol:. p:. ().  </li><li>. <u></u>. <i></i>. ISSN:. vol:. p:. ().  </li><li>. <u></u>. <i></i>. ISSN:. vol:. p:. ().  </li></ol><li><strong>Conferencias Académicas</strong></li><ol><li>Luis Wanumen, Hector Florez. <u>Architectural Approaches for Phonemes Recognition Systems</u>. p:267-279. Bogotá, Colombia. (2018). <a href='https://doi.org/10.1007/978-3-030-01535-0_20' target='_blank'><span class='fas fa-external-link-alt'></span></a></li><li>Daniel Sanchez, Hector Florez. <u>Model Driven Engineering Approach to Manage Peripherals in Mobile Devices</u>. p:353-364. Melbourne, Australia. (2018). <a href='https://doi.org/10.1007/978-3-319-95171-3_28' target='_blank'><span class='fas fa-external-link-alt'></span></a></li><li>. <u></u>. . (). </li><li>. <u></u>. . (). </li><li>. <u></u>. . (). </li><li>. <u></u>. . (). </li></ol></ul><ul></div></div><br>