Aplicaciones bioinformaticas para el análisis de microorganismos

El proyecto de aplicaciones bioinformaticas para el análisis de microorganismos está enfocado a realizar análisis computacional de mutaciones del virus de la hepatitis C (VHC) asociados a resistencia a los antivirales de acción directa (AAD). La infección crónica por el VHC sigue siendo un grave problema de salud pública a nivel mundial, afectando a 200 millones de personas y ocasionando unas 10.000 muertes al año. Por tanto es importante determinar la variabilidad del VHC en los genes NS3, NS5A y NS5B, diana de AAD, para poder determinar su posible impacto en el tratamiento con nuevos AAD en pacientes infectados con VHC, prevenir potenciales fallos terapéuticos y optimizar los futuros regímenes terapéuticos, escogiendo los AAD más adecuados para cada paciente.

Año de Inicio: 2013-01-01
Autores

Hector Florez
Karina Salvatierra

Software

PSSA
BMA

Publicaciones

Artículos en Revista

Salvatierra Karina, Vera Marcos, Lloret María Antonia, Florez Hector. In Silico Docking Study: Antiviral Activity of Sofosbuvir Against NS5 Protein from Sika Virus. . ISSN: . vol:. p:. (2018).
Salvatierra Karina, Florez Hector, Lopez Labrador Xavier. Coevolution Analysis of Proteins NS3 and NS5B of Hepatitis C Virus in Geotype 1B Isolates. . ISSN: . vol:. p:. (2018).
Salvatierra Karina, Florez Hector. Bioinformatics Approach to Analyze Influenza Viruses. Communications in Computer and Information Science. ISSN:1865-0929. vol:916. p:442-452. (2018).
Guardiola Mauro, Salvatierra Karina, Florez Hector. Computer analysis of resistance mutations to HCV NS5A antivirals. International Journal of Infectious Diseases. ISSN:1201-9712. vol:73S. p:382-383. (2018).
Salvatierra Karina, Florez Hector. Computational analysis of resistance mutations in the hepatitis C virus. Vínculos. ISSN:1794-211X. vol:15. p:27-33. (2018).
Florez Hector, Salvatierra Karina. A Web-Based Approach for Analyzing Microorganism Sequences. Communications in Computer and Information Science. ISSN:1865-0929. vol:742. p:96-107. (2017).
Florez Hector, Salvatierra Karina. Using bioinformatics methods to analyze influenza viruses. . ISSN: . vol:. p:65-72. (2017).
Florez Hector, Salvatierra Karina. Bioinformatics Study of Mutations of Resistance to Antivirals in the NS5A Gen of HCV. Information. ISSN:1343-4500. vol:20 (9A). p:6665-6672. (2017).
Florez Hector, Salvatierra Karina. Computational analysis of resistance mutations to new direct acting antivirals in the Hepatitis C virus. . ISSN: . vol:. p:65-66. (2017).
Florez Hector, Salvatierra Karina. Computational analysis of E1 gene of chikungunya virus to identify genotypes. . ISSN: . vol:. p:60-61. (2017).
Florez Hector, Salvatierra Karina. A Tool for Analyzing Mutations in Biomedical Microorganisms. . ISSN: . vol:. p:25-33. (2017).
Salvatierra Karina, Florez Hector. Pathogen Sequence Signature Analysis (PSSA): A software tool for analyzing sequences to identify microorganism genotypes. F1000 Research. ISSN:2046-1402. vol:6 (21). p:1-8. (2017).
Salvatierra Karina, Florez Hector. Prevalence of hepatitis B and C infections in hemodialysis patients. F1000 Research. ISSN:2046-1402. vol:5 (1910). p:1-6. (2016).
Salvatierra Karina, Florez Hector. Biomedical Mutation Analysis (BMA): A software tool for analyzing mutations associated with antiviral resistance. F1000 Research. ISSN:2046-1402. vol:5 (1141). p:1-9. (2016).
Salvatierra Karina, Florez Hector. Hepatitis C virus NS3 protease resistance testing: analysis computational to detect resistance mutations. . ISSN: . vol:. p:6. (2016).
Salvatierra Karina, Florez Hector. Computational analysis to detect resistance mutations to direct acting antivirals in Hepatitis C virus. . ISSN: . vol:. p: 47. (2016).
Salvatierra Karina, Florez Hector. Análisis del Virus de la Hepatitis C en pacientes en hemodiálisis. Infectio. ISSN:0123-9392. vol:20 (3). p:130-137. (2015).
Florez Hector, Salvatierra Karina. Análisis computacional de mutaciones de resistencias del virus de la hepatitis C. . ISSN: . vol:. p:21. (2015).
Salvatierra Karina, Florez Hector. Análisis Computacional de Mutaciones de Resistencias a Inhibidores de la Proteasa NS3 Y Polimerasa NS5B del Virus de la Hepatitis C. Biomédica. ISSN:0120-4157. vol:35. p:125. (2015).

Conferencias Académicas

Salvatierra Karina, Vera Marcos, Lloret María Antonia, Florez Hector. In Silico Docking Study: Antiviral Activity of Sofosbuvir Against NS5 Protein from Sika Virus. p:. Buenos Aires, Argentina. (2018).
Salvatierra Karina, Florez Hector, Lopez Labrador Xavier. Coevolution Analysis of Proteins NS3 and NS5B of Hepatitis C Virus in Geotype 1B Isolates. p:. Santiago, Chile. (2018).
Salvatierra Karina, Florez Hector. Bioinformatics Approach to Analyze Influenza Viruses. p:442-452. Medellin, Colombia. (2018).
Guardiola Mauro, Salvatierra Karina, Florez Hector. Computer analysis of resistance mutations to HCV NS5A antivirals. p:382-383. Buenos Aires, Argentina. (2018).
Salvatierra Karina, Florez Hector. Computational analysis of resistance mutations in the hepatitis C virus. p:27-33. . (2018).
Florez Hector, Salvatierra Karina. A Web-Based Approach for Analyzing Microorganism Sequences. p:96-107. Cartagena, Colombia. (2017).
Florez Hector, Salvatierra Karina. Using bioinformatics methods to analyze influenza viruses. p:65-72. Toronto, Canada. (2017).
Florez Hector, Salvatierra Karina. Bioinformatics Study of Mutations of Resistance to Antivirals in the NS5A Gen of HCV. p:6665-6672. Bandung, Indonesia. (2017).
Florez Hector, Salvatierra Karina. Computational analysis of resistance mutations to new direct acting antivirals in the Hepatitis C virus. p:65-66. Madison, Estados Unidos. (2017).
Florez Hector, Salvatierra Karina. Computational analysis of E1 gene of chikungunya virus to identify genotypes. p:60-61. Madison, Estados Unidos. (2017).
Florez Hector, Salvatierra Karina. A Tool for Analyzing Mutations in Biomedical Microorganisms. p:25-33. Orlando, Estados Unidos. (2017).
Salvatierra Karina, Florez Hector. Pathogen Sequence Signature Analysis (PSSA): A software tool for analyzing sequences to identify microorganism genotypes. p:1-8. . (2017).
Salvatierra Karina, Florez Hector. Prevalence of hepatitis B and C infections in hemodialysis patients. p:1-6. . (2016).
Salvatierra Karina, Florez Hector. Biomedical Mutation Analysis (BMA): A software tool for analyzing mutations associated with antiviral resistance. p:1-9. . (2016).
Salvatierra Karina, Florez Hector. Hepatitis C virus NS3 protease resistance testing: analysis computational to detect resistance mutations. p:6. Hyderabad, India. (2016).
Salvatierra Karina, Florez Hector. Computational analysis to detect resistance mutations to direct acting antivirals in Hepatitis C virus. p: 47. San José, Costa Rica. (2016).
Salvatierra Karina, Florez Hector. Análisis del Virus de la Hepatitis C en pacientes en hemodiálisis. p:130-137. . (2015).
Florez Hector, Salvatierra Karina. Análisis computacional de mutaciones de resistencias del virus de la hepatitis C. p:21. Buenos Aires, Argentina. (2015).
Salvatierra Karina, Florez Hector. Análisis Computacional de Mutaciones de Resistencias a Inhibidores de la Proteasa NS3 Y Polimerasa NS5B del Virus de la Hepatitis C. p:125. Bogotá, Colombia. (2015).

Diseño de soluciones en el contexto de ingenía dirigida por modelos

Por medio de la creación de metamodelos y transformaciones modelo a modelo y modelo a texto, se desea crear proyectos de software de forma semiautomática, a partir de la creación de un único modelo conceptual.

Año de Inicio: 2013-01-01
Autores

Hector Florez
Daniel Sanchez
Oscar Mendez

Software

CFP
RIS
DevPHP
RIWA
PHPGen

Publicaciones

Libros

Florez Hector. Sistemas Digitales. Ediciones de la U. ISSN:978-958-762-190-7. 2014.

Capítulos de Libro

Florez, Hector. Human Factors in Automated Analysis for Enterprise Models. IGI Global. ISSN:180619075135. 2019.
Florez Hector, Sanchez Mario, Villalobos Jorge. Drafting Enterprise Models. IGI Global. ISSN:9781522555223. 2018.

Artículos en Revista

Florez Hector, Leon Marcelo. Model Driven Engineering Approach to Configure Software Reusable Components. Communications in Computer and Information Science. ISSN:1865-0929. vol:942. p:352-363. (2018).
Sanchez Daniel, Florez Hector. Model Driven Engineering Approach to Manage Peripherals in Mobile Devices. Lecture Notes in Computer Science. ISSN:0302-9743. vol:10963. p:353-364. (2018).
Sanchez Daniel, Mendez Oscar, Florez Hector. An Approach of a Framework to Create Web Applications. Lecture Notes in Computer Science. ISSN:0302-9743. vol:10963. p:341-352. (2018).
Sanchez Daniel, Mendez Oscar, Florez Hector. Applying the 3-layer Model in the Construction of a Framework to Create Web Applications. . ISSN: . vol:. p:364-369. (2017).
Florez Hector, Sanchez Mario, Villalobos Jorge. Analysis of Imprecise Enterprise Models. Lecture Notes in Business Information Processing. ISSN:1865-1348. vol:248. p:349-364. (2016).
Florez Hector, Sanchez Mario, Villalobos Jorge. A Catalog of Automated Analysis Methods for Enterprise Models. SpringerPlus. ISSN:2193-1801. vol:5 (406). p:1-24. (2016).
Florez Hector. Metamodels composition strategy for the model driven engineering context. Vínculos. ISSN:1794-211X. vol:44. p:109-120. (2015).
Gomez Paola, Sanchez Mario, Florez Hector, Villalobos Jorge. An Approach to the Co-creation of Models and Metamodels in Enterprise Architecture Projects. Journal of Object Technology. ISSN:1660-1769. vol:13 (3). p:1-29. (2014).
Florez Hector, Sanchez Mario, Villalobos Jorge. Extensible Model-based Approach for Supporting Automatic Enterprise Analysis. . ISSN: . vol:. p:32-41. (2014).
Florez Hector, Sanchez Mario, Villalobos Jorge. iArchiMate: A Tool for Managing Imperfection in Enterprise Models. . ISSN: . vol:. p:201-210. (2014).
Florez Hector, Sanchez Mario, Villalobos Jorge. Supporting Drafts for Enterprise Modeling. . ISSN: . vol:. p:200-206. (2014).
Florez Hector, Sanchez Mario, Villalobos Jorge. Embracing Imperfection in Enterprise Architecture Models. CEUR Workshops Proceedings. ISSN:1613-0073. vol:1023. p:8-17. (2013).
Florez Hector. Adapting models in metamodels composition processes. Vínculos. ISSN:1794-211X. vol:10 (1). p:96-108. (2013).
Florez Hector. Software Product Lines based on Model Transformation Chains. . ISSN: . vol:. p:. (2013).

Conferencias Académicas

Florez Hector, Leon Marcelo. Model Driven Engineering Approach to Configure Software Reusable Components. p:352-363. Bogotá, Colombia. (2018).
Sanchez Daniel, Florez Hector. Model Driven Engineering Approach to Manage Peripherals in Mobile Devices. p:353-364. Melbourne, Australia. (2018).
Sanchez Daniel, Mendez Oscar, Florez Hector. An Approach of a Framework to Create Web Applications. p:341-352. Melbourne, Australia. (2018).
Sanchez Daniel, Mendez Oscar, Florez Hector. Applying the 3-layer Model in the Construction of a Framework to Create Web Applications. p:364-369. Orlando, Estados Unidos. (2017).
Florez Hector, Sanchez Mario, Villalobos Jorge. Analysis of Imprecise Enterprise Models. p:349-364. Ljubljana, Eslovenia. (2016).
Florez Hector, Sanchez Mario, Villalobos Jorge. A Catalog of Automated Analysis Methods for Enterprise Models. p:1-24. . (2016).
Florez Hector. Metamodels composition strategy for the model driven engineering context. p:109-120. . (2015).
Gomez Paola, Sanchez Mario, Florez Hector, Villalobos Jorge. An Approach to the Co-creation of Models and Metamodels in Enterprise Architecture Projects. p:1-29. . (2014).
Florez Hector, Sanchez Mario, Villalobos Jorge. Extensible Model-based Approach for Supporting Automatic Enterprise Analysis. p:32-41. Ulm, Alemania. (2014).
Florez Hector, Sanchez Mario, Villalobos Jorge. iArchiMate: A Tool for Managing Imperfection in Enterprise Models. p:201-210. Ulm, Alemania. (2014).
Florez Hector, Sanchez Mario, Villalobos Jorge. Supporting Drafts for Enterprise Modeling. p:200-206. Pereira, Colombia. (2014).
Florez Hector, Sanchez Mario, Villalobos Jorge. Embracing Imperfection in Enterprise Architecture Models. p:8-17. Riga, Letonia. (2013).
Florez Hector. Adapting models in metamodels composition processes. p:96-108. Cartagena, Colombia. (2013).
Florez Hector. Software Product Lines based on Model Transformation Chains. p:. Orlando, Estados Unidos. (2013).

Aplicaciones móviles en contextos empresarial

Mediante la creación de aplicaciones móviles empresariales se crean soluciones de negocio específicas. Además, dichas aplicaciones contribuyen a la generación de nuevas empresas

Año de Inicio: 2014-01-01
Autores

Hector Florez
Daniel Sanchez

Software

Black Jack
ARtesanias App
TelApp
BlackJack App

Publicaciones

Artículos en Revista

Wanumen Luis, Florez Hector. Architectural Approaches for Phonemes Recognition Systems. Communications in Computer and Information Science. ISSN:1865-0929. vol:942. p:267-279. (2018).
Sanchez Daniel, Florez Hector. Model Driven Engineering Approach to Manage Peripherals in Mobile Devices. Lecture Notes in Computer Science. ISSN:0302-9743. vol:10963. p:353-364. (2018).
Joya Juan, Prieto Karen, Florez Hector. Comunicación Síncrona Mediante Arquitectura Orientada a Servicios para Aplicaciones en Dispositivos . . ISSN: . vol:. p:422-427. (2015).
Rincon Sebastian, Cardenas Ivan, Florez Hector. M-Commerce basado en Realidad Aumentada. . ISSN: . vol:. p:284-289. (2015).
Gonzalez Angela, Barrera Ricardo, Florez Hector. M-Marketplaces para la Comercialización de Productos y Servicios. . ISSN: . vol:. p:290-294. (2015).
Joya Juan, Florez Hector. Communication of Mobile Devices through Bluetooth Technology. Vínculos. ISSN:1794-211X. vol:11 (2). p:92-98. (2014).

Conferencias Académicas

Wanumen Luis, Florez Hector. Architectural Approaches for Phonemes Recognition Systems. p:267-279. Bogotá, Colombia. (2018).
Sanchez Daniel, Florez Hector. Model Driven Engineering Approach to Manage Peripherals in Mobile Devices. p:353-364. Melbourne, Australia. (2018).
Joya Juan, Prieto Karen, Florez Hector. Comunicación Síncrona Mediante Arquitectura Orientada a Servicios para Aplicaciones en Dispositivos . p:422-427. Cartagena, Colombia. (2015).
Rincon Sebastian, Cardenas Ivan, Florez Hector. M-Commerce basado en Realidad Aumentada. p:284-289. Cartagena, Colombia. (2015).
Gonzalez Angela, Barrera Ricardo, Florez Hector. M-Marketplaces para la Comercialización de Productos y Servicios. p:290-294. Cartagena, Colombia. (2015).
Joya Juan, Florez Hector. Communication of Mobile Devices through Bluetooth Technology. p:92-98. . (2014).